Chronic & Acute Pain

Inflammation is the most common cause of pain. Relieve inflammation and you relieve pain. Inflammation is caused by the release of PGE1 prostaglandin and is sustained by an enzyme called cyclooxygenase 2 (COX2). It is interesting that cancer cells are surrounded by an abnormally heavy concentration of COX2 enzymes. If one could inhibit COX2 enzymes, they could control inflammation and possibly cancer. (This is substantiated by evidence of less cancers among chronic aspirin users). Many years ago drug companies found that aspirin inhibited COX2 but at the same time inhibited COX2 which is a protective prostaglandin for the lining of the digestive tract and blood vessels. Without adequate COX2 you can have ulcers and leaking of the blood vessels. So, for temporary use, aspirin is fine but extended use causes serious side effects. Then came the “miracle” of the COX2 inhibitors – Vioxx, Bextra, Celebrex and others in the market. (Read More)